Protein Details: Calcium-activated chloride channel regulator 1

Protein ID

ICDB_Pro_0909

Protein Name

Calcium-activated chloride channel regulator 1

Gene Name

CLCA1

Organism

Equus caballus (Horse)

Length

913 amino acids

AlphaFoldDB

AF-Q2TU62-F1-model_v4.pdb

Function

May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia; mucus hypersecretion; cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC (By similarity).

Sequence

MGSFKSSVFILVLHLLEGALSNSLIHLNNNGYEGIVIAIDPNVPEDETLIQQIKDMVTQASPYLFEATEKRFYFKNVAILVPENWKTKPEYERPKLETYKNADVLVAEPNPPGNDQPYTEQMGKCGEKGERIYFTPDFLAGKRLDEYGPQGRVFVHEWAHLRWGLFNEYNDDQKFYLSNKEIKPVKCSADIAGKNVVNHCQGGSCATKPCRRDRVTGLYAQECEFIPDEQQTEKASIMFSQSIDSVVEFCTEENHNREAPNMQNQRCNLRSTWEVIRDSEDFKKTTPMTAQPPQPTFSLLQIGQRIVCLVLDKSGSMAIGDRLKRLTQAGKLFLLQTVEQGSWVGMVTFDSAAYVQSALRQIKGGTDRDALTKSLPTVASGGTSICSGLRSAFTVIRKKYKTDGSEIVLLTDGEDNTISSCFNEVKQSGAIIHTVALGPSAAAELEELSKMTGGLQTYASDQAQNNGLIDAFGALSSGNGAVSQHSIQLVSRGSTLQNSQWMNGTVIVDSTVGNDTLFLITWTSQPPQILLWDPSGKKQDGFVVDTNTKMAYLQVPGTAKVGTWTYSLQASSQTLTLTVTSRASSATLPPVTVTSKVNKDTGKFPSPVVVYAKIHQGGLPILRATVTALIESVDGKTVTLELLDNGAGADATKDDGIYSRYFTAYNTNGRYSIKVWALGGVNAARQMGISQQNGAMYRAGRMKNGEIIWNPPRPKINIDDLLSKQVPFSRTSSGGSFVASNVPNAPIPDLFPPCQITDLKAKIQGDSLINLTWTAPGDDYDHGRADRYIIRISTNILDLRDKFNDSLQVNTTDLIPKEATSEEVFVFKPENIAFENGTDLFIAIQAVDEVDLESEISNIAQVSLFLPPQTPPETPSPSLPCPDSNITSAIPGIHILKVMWKWLGELQLSVALG

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 156; /ligand="Zn(2+)"; /ligand_note="catalytic"; BINDING 160; /ligand="Zn(2+)"; /ligand_note="catalytic"; BINDING 167; /ligand="Zn(2+)"; /ligand_note="catalytic";

Disease

Location

Expressed in mucin-producing cells in the respiratory and intestinal tracts; cutaneous sweat glands; and renal mucous glands (at protein level). Strong overexpression in the airways of horses with recurrent airway obstruction (at protein level).

DOI ID

10.1369/jhc.4a6599.2005

RefSeq

NP_001075268.1